Mutations of genes involved in signaling pathways, including APC (the Wnt pathway), KRAS (the EGFR/MAPK pathway), PIK3CA (the PI3K/Akt pathway) and SMAD-2/3/4 (the TGF-beta pathway), are commonly associated with various CRC subtypes [2]. The gene discussed is APC; the disease is colorectal carcinoma.