BRAF and melanoma: In fact, melanoma cell lines treated for only 24 h [68,69,74,75] or from 48 to 72 h [74,76,77,78] with BRAFi, MEKi, or ERKi, display spindle-shaped and/or flat morphology, regardless of the MAPK oncogenic driver (BRAF or NRAS mutant) [68].