TARDBP and amyotrophic lateral sclerosis: In fact, the HSP70/CHIP/BAG1 complex favored the disposal of TDP-43, TDP-35 and TDP-25-insoluble species via UPS, whereas the HSP70/BAG3/HSPB8 complex, also known as the chaperone-assisted selective autophagy (CASA) complex, promoted their degradation via autophagy in different ALS cell models [36,37].