RAB7A and axonal neuropathy: Indeed, CMT2B, in general, is characterized by mild-to-absent motor deficits [3,23] while, in the patient harboring the p.K126R mutation, electrophysiology demonstrated an axonal neuropathy with predominant motor involvement, early-onset walking difficulties, progressive distal muscle wasting and weakness, particularly in lower limbs, and only mild sensory signs [22].