GPR183 and inflammatory response: To further pursue whether GPR183 plays a role in the response of peritoneal B1 cells to bacterial or inflammatory stimuli in a different model, we treated GPR183 KO and WT mice with indomethacin, a nonsteroidal anti-inflammatory drug (NSAID) with the ability to increase the permeability of the intestinal epithelial barrier and to cause intestinal inflammation [42,43,44].