Recently TRPM2-mediated Ca2+ release from lysosomes was found to promote autophagic degradation in vascular smooth muscle cells, thereby causing cell death [106], and knockout of TRPM2 attenuated hypertension in spontaneously hypertensive rats by reconstituting autophagy in endothelial cells and vascular smooth muscle cells [107]. This evidence concerns the gene TRPM2 and hypertensive disorder.