TRPM2 and early-onset autosomal dominant Alzheimer disease: Therefore, TRPM2 is closely related to many human diseases, such as myocardial infarction [54], ischemic stroke [55,56,57], Alzheimer’s disease [58,59], cardiomyopathy [60], atrial fibrillation [61], hypertension [62], atherosclerosis [63], inflammatory lung injury [51,64], diabetes [65], ischemic kidney disease [66], and many cancers [67].