SMAD3 and cancer: Other cancer cell types showed horizontal transfer of the molecules responsible for increasing cellular migration and aiding the invasion of recipient cancer cells mediated by EVs, such as the transfer of Caveolin-1 in breast cancer cells, Wnt5b protein in colon cancer, and CXC chemokine receptor 4 (CXCR4) or SMAD3 in hepatocarcinoma cells [102].