Several epigenetic modulators, such as VEGF (vascular endothelial growth factor), CXCR4 (CXC chemokine receptor 4), EPHB2 (EPH Receptor B2), miR-103, or any other sort of long non-coding RNAs, are carried by cancer-derived EVs to stimulate angiogenesis. This evidence concerns the gene EPHB2 and cancer.