In the current study, we found that IRF1 was significantly upregulated in cells infected by H1N1, H7N9, and SARS-CoV-2, respectively (Figure 8D), and then demonstrated its regulatory mechanisms after viral infection (Figure 8E); a novel lncRNA-34087.27 was upregulated after these respiratory viruses’ infection activated the expression of IRF1 mRNA as a competitive endogenous RNA by adsorbing miR-302b-3p. Here, IRF1 is linked to viral infectious disease.