We found that overexpression of NGAL in an ADPKD mouse model (Pkd1L3/L3 × NGALTg/Tg mice) reduced cyst progression and prolonged the lifespan of Pkd1L3/L3 mice, accompanied by changes in a series of molecular pathways involved in proliferation, apoptosis and fibrosis [31]. This evidence concerns the gene LCN2 and cyst.