PKD1 and autosomal dominant polycystic kidney disease: Previously, we established an ADPKD mouse model called Pkd1L3/L3 (in a C57BL/6 genetic background) [17] by inserting a loxP site and a loxP-flanked mc1-neo cassette in introns 30 and 34 of the Pkd1 gene, respectively (L3 means three loxP sites within the allele), to generate the conditional gene mutation.