On the other hand, mechanical loading can have beneficial or detrimental effects on differentiated cardiomyocytes, depending on its specific characteristics [29], by activating pro-inflammatory factors, such as IL-1β, TNF-α, IL-6, and NF-kB, as well as muscle atrophy and pro-apoptotic factors, such as myostatin, muscle-specific ubiquitin ligase Atrogin-1 (MaFbx), FoxO1, and p53, which have been negatively implicated in cell growth and survival, inducing cardiac muscle wasting and promoting heart failure [29,30,31,32,33,34,35,36]. This evidence concerns the gene FBXO32 and heart failure.