VHL and nonpapillary renal cell carcinoma: To examine if VHL regulates TGFBI and NFKB2 in other ccRCC cell lines, we generated VHL-overexpressed sublines of two other VHL-defective ccRCC cell lines, RCC4 and RCC10, and showed that VHL restoration in these cells also led to the lower expression of TGFBI and NFKB2/p100 at the protein level (Figure 5M).