NFKB1 and cancer: TGFBI protein upregulation is validated as being associated with metastasis and poorer survival in ccRCC [25,26], but there is no publication yet about the prognostic significance of NFKB2 protein in ccRCC, although other signaling players in the non-canonical NF-κB pathway (NIK, IKKα, and RelB) were shown to correlate with poorer cancer-specific survival [29].