While our results indicate that NFKB2 and VHL physically interact with each other, and K72 of NFKB2 affects NFKB2 stability in a VHL-dependent manner (Figure 6E,F), future studies will more rigorously examine whether these ubiquitinations depend on prolyl hydroxylation and their functional role in ccRCC development. Here, VHL is linked to nonpapillary renal cell carcinoma.