At the transcriptomic level, in both ccRCC cell lines and TCGA tumors, 786-O-Ctrl clustered with VHLmut cases whereas 786-O-VHL clustered with VHLWT cases (Figure 2F–I), supporting VHL as a key regulator in ccRCC development. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.