GSEA of the differentially expressed genes between VHLmut and VHLWT ccRCC cell lines showed that pathways such as hypoxia, glycolysis and E2F targets were enriched in VHLmut cell lines, whereas KRAS signaling and apoptosis were enriched in VHLWT cell lines (Figure 2G). This evidence concerns the gene KRAS and nonpapillary renal cell carcinoma.