NFKB2 and nonpapillary renal cell carcinoma: While our results indicate that NFKB2 and VHL physically interact with each other, and K72 of NFKB2 affects NFKB2 stability in a VHL-dependent manner (Figure 6E,F), future studies will more rigorously examine whether these ubiquitinations depend on prolyl hydroxylation and their functional role in ccRCC development.