CNR2 and major depressive disorder: For example, CB2-CXCR4 and CB2-GPR55 dimers have been associated with cancer progression, while CB1-A2A and CB1-D2 heteromers have been suggested to have physiological implications in neurodegenerative disorders such as AD, PD, epilepsy, autism, but also in neuropsychiatric pathologies such as anxiety, depression, and psychotic disorders [36,88].