Notably, the autosomal recessive syndrome caused by SMPD4 loss shares several overlapping features with the Galloway –Mowat syndrome (GAMOS), which is associated with mutations in components of the Nup107-160 nuclear pore sub-complex (e.g., Nup133 and Nup107) [117]. This evidence concerns the gene SMPD4 and Galloway-Mowat syndrome.