MLH1 and cancer: On the other hand, cancer-associated hypermethylation was found in promoters of genes involved in DNA repair (e.g., BRCA1 [184], MLH1 [185], MGMT [186]), apoptosis (e.g., p53 target genes DAPK1 [187] and CASP8 [188]), and immune response (e.g., CXCL9, CXCL10 [189], NKG2D [190], and MHC1 related genes [191]).