COASY and Alzheimer disease: In a genome-wide screening of blood DNAm levels in amnestic mild cognitive impairment (aMCI) and AD patients, hypomethylation in the NCAPH2/LMF2 promoter region and hypermethylation in the COASY and SPINT1 gene promoter regions were identified [157] and proposed as potential diagnostic biomarkers for AD and aMCI.