GRN and Alzheimer disease: To evaluate the interaction of the biological variables under study and the diagnostic groups, partial correlation analyses were performed among the CSF EV concentration/size ratio, CysC and PGRN (neurotrophic factor), Aβ 40, Aβ 42, p-Tau 181, Tau, Aβ 42/Aβ 40 and p-Tau 181/Aβ 42 (core biomarkers for AD).