IGF1R signaling is curtailed by miR-139-5p, miR-214 and miR-375 in multiple carcinoma cell types [36,37,38], miR-378 in primary cardiomyocytes [39], miR-100 in 3T3-L1 adipocytes [40], and miR-133 in murine C2C12 cell myogenesis [41], where all aforementioned miRNAs directly target and reduce IGF1R levels. Here, IGF1R is linked to carcinoma.