In previous proteomics studies using KM12 isogenic cell lines, many identified proteins were described as key molecules in CRC, as VEGFA, ERBB2, EGFR, MMP7, FGFR4, cadherin-17 (CDH17), or IL13Rα2 [13,14,24,43]. Here, ERBB2 is linked to colorectal carcinoma.