Moreover, METTL3 suppresses autophagy by methylating FOXO3 (in an 800 bp region of FOXO3 3′UTR containing the m6A modification site), which subsequently downregulates the expression of ULK1, ATG5, ATG7, ATG12, ATG16L1, and MAP1LC3B in human sorafenib-resistant hepatocellular carcinoma [82]. The gene discussed is FOXO3; the disease is hepatocellular carcinoma.