METTL3 positively regulates autophagy by increasing the expression of ATG5, ATG7, and LC3B through m6A modification of their mRNA, whereas β-elemene reverses gefitinib resistance in gefitinib-resistant PC9GR and HCC827GR derived from NSCLC cells by inhibiting METTL3-mediated autophagy [81]. This evidence concerns the gene METTL3 and non-small cell lung carcinoma.