Additional pathologies, such as cerebrovascular pathologies of variable severity (from frank infarcts to microscopic cortical infarcts to microvascular disease), cortical and subcortical Lewy bodies, TDP-43 inclusions, and lesions associated with Frontotemporal Lobar Degenerations (FTLD) often co-exist with canonical AD pathologic lesions [3]. The gene discussed is TARDBP; the disease is Alzheimer disease.