GED-0507-34 Levo showed improvement of intestinal fibrosis in DSS-induced chronic colitis in mice, reducing the activation of myofibroblasts and the expression of the main pro-fibrotic molecules including TGF-β, Smad3, IL-13 and connective tissue growth factor (CTGF) [81]. The gene discussed is CCN2; the disease is Chronic colitis.