In three-dimensional (3D) cultures from human lung adenocarcinoma, SCD1 was demonstrated to control the Hippo pathway by modulating the activity of its main effectors, Yes-associated protein (YAP) and transcriptional co-activator with a PDZ-binding motif (TAZ), an effect dependent on the activation of the Wnt/β-catenin pathway [55]. The gene discussed is SCD; the disease is lung adenocarcinoma.