Dysregulation of FAO in cancer has been correlated with the overexpression of various FAO enzymes; among them, a relevant role in cancer metabolic rewiring is attributed to carnitine palmitoyltransferase 1 (CPT1), the key rate-limiting enzyme of FAO that is responsible for the transfer of FAs from cytosol to mitochondria (Figure 1) [20]. This evidence concerns the gene CPT1A and cancer.