SOD1 and non-small cell lung carcinoma: Another study [79] demonstrating the pro-apoptotic role of ceramide in lung cancer showed that treatment of NSCLC H1299 cells with exogenous C8-ceramide promoted the switch of superoxide dismutase 1 (SOD1) to SOD2, which increased the endogenous levels of ROS, inhibiting cell proliferation and inducing apoptosis.