Three macrophage subsets have been shown to express Lyve1 in atherosclerotic plaques of Ldlr−/− mice using scRNAseq [6] It has been suggested that atherosclerotic aortas contain resident macrophages originating from an embryonic pool, which, upon atherosclerosis development, are replaced by, or accompanied by, recruited monocyte-derived macrophages that adopt a resident-like macrophage phenotype and who play a role in endocytosis [7]. The gene discussed is LYVE1; the disease is atherosclerosis.