LYVE1 and ischemic stroke: To gain insight into the possible role of LYVE-1 res-like macrophages in the destabilization of human atherosclerotic plaques, we used specimens of internal carotid plaques from a previously published cohort study [33] from symptomatic CAD patients with their first episode of an ipsilateral ischemic stroke, as well as specimens from asymptomatic patients (no history of ischemic symptoms) undergoing an endarterectomy for a severe carotid stenosis.