The levels of AUF1 protein, which destabilizes MAT1A mRNA, Mat1A-AUF1 ribonucleoprotein, HuR protein, which stabilizes MAT2A mRNA, and the Mat2A-HuR ribonucleoprotein increase in HCC of genetically susceptible F344 rats and in human HCC with poorer prognosis (HCCP), and undergo low/no increase in BN HCC and human HCC with better prognosis (HCCB) [50]. This evidence concerns the gene HNRNPD and hepatocellular carcinoma.