The decrease of MAT1A expression in alcoholic hepatitis, liver cirrhosis and HCC [16,31] on the whole depends, transcriptionally, on the methylation of CpG of the MAT1A promoter and the deacetylation of histone H4 and, post-transcriptionally, on the interaction of MAT1A mRNA with the AUF1 protein that increases its decay [32]. Here, MAT1A is linked to cirrhosis of liver.