Therefore, chronically SAM deficient MAT1A-KO mice, even in the presence of MAT2A induction, undergo hepatomegaly without histologic abnormalities at three months of age, steatosis of 25–50% of hepatocytes and infiltration of mononuclear cell in periportal areas, at eight months, and HCC at 18 months of age [24]. This evidence concerns the gene MAT2A and hepatocellular carcinoma.