PAX2 and diabetes mellitus: In the model of streptozotocin (STZ)-induced acute diabetes mellitus, protein synthesis in the renal cortex is increased at three days and falls to the level equal to control rats at seven days, while proteolysis is decreased for at least seven days with the accumulation of CMA substrates (Pax2), indicating that reduced CMA may be the main reason for renal hypertrophy in diabetes mellitus [20].