CTNS and cystinosis: In Ctns−/− mice PTC, CMA activators rescued LAMP2A mislocalization and increased cell survival [74], and in human Ctns-KO PTC, CMA activators rescued Rab11 expression and trafficking [75], suggesting that CMA up-regulation is a potential strategy for the treatment of cystinosis, independent of therapies of decreasing lysosomal overload such as cysteamine [56].