However, analysis of the TG2 interactors in the APP23 brain and concurrently of the APP23 proteome has also revealed that less than 1% of the TG2 partners emerged as increased in the AD-mimicking model in our all-round investigation, suggesting modification of a specific set of proteins in brain post-translationally by transglutaminase as part of the pathological process, rather than transcriptionally. The gene discussed is TGM2; the disease is Alzheimer disease.