TGM2 and Alzheimer disease: As TG2 is associated with both SP and its precursor diffuse plaques in AD, as well as both early vascular Aβ deposition and CAA [10,22,29], we analyzed animal brains at a disease duration (18 months) in which these Aβ pathologies are prominently present in APP23 mice, but have not yet developed to end stage disease [27].