ApoE, a well-known risk factor of AD and linked to Aβ pathology in APP23 mice in previous work [21,37,38], was revealed as a TG2 partner in both the WT and the APP23 interactome (Figure 5B, Table 2) and was also found to be increased in the APP23 brains in this study but at a lower level of confidence (54%). The gene discussed is APOE; the disease is Alzheimer disease.