Previous studies suggested that fruiting body extracts from mushrooms, including Leucopaxillus giganteus, and Pleurocybella porrigens may stimulate host immunity by suppressing the expression of Axl, PD-L1, and PD-L2 in the non-small cell lung cancer cell lines A549 and H3255 cells [23,24]. Here, CD274 is linked to non-small cell lung carcinoma.