Additional in vitro and in vivo evidence reveal a role for BMP9 in the regulation of glucose and lipid metabolism as well as the hepatic inflammatory response, having been associated with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) development, although somehow contradictory results have been described [9,10,11,12]. The gene discussed is GDF2; the disease is metabolic dysfunction-associated steatotic liver disease.