Based on domain mapping results, interaction of the DD domain of RIPK1 with the transcription activation domain of SOX9 would abrogate not only the transcriptional activation of pro-survival and stemness-related gene transcription by SOX9 transcription factor but also RIPK1-mediated cancer cell death by necroptosis in the cytoplasm, resulting in cancer stem cell survival in HGOC. The gene discussed is SOX9; the disease is cancer.