Note that this correspondence between glioma subtypes and the aging healthy brain refers to developmental stages of the underlying cellular programs and not to the age of incidence of the tumors, which appears in a different order, namely of largest age for IDH-wt gliomas (median age of incidence above 50 years) followed by IDH-O (about 45 years) and IDH-A observed in youngest patients (about 40 years) [21,88]. This evidence concerns the gene IDH1 and glioma.