As a next type of age profile, we studied a set of GPCR which were found to hypomethylate in part of the gliomas, particularly the IDH-wt group M1 and the IDH-A groups M2–M3 comprising the low-GCIMP tumors of inferior prognosis among the IDH-mut gliomas (see above Figure 8 and Figure 10b). Here, IDH1 is linked to central nervous system cancer.