IDH1 and central nervous system cancer: Interestingly, aging profiles of genes from these chromosomes of the healthy brain show overexpression for Chr.7 and underexpression for Chr.10 in babies and adolescent thus resembling the Chr.7+/Chr.10− dose responses of IDH-wt (M1) gliomas, while the aging profile of Chr.19 shows underexpression in elderly thus resembling the Chr.19− dose effect in IDH-O (M5) gliomas (Figure 8e and Figure A9).