Indeed, we previously demonstrated that EVs derived from NSCLC were internalized into MCs and activated them to release several mediators, including TNF-α and monocyte chemoattractant protein 1 (MCP-1)/ CC chemokine ligand 2 (CCL2), in addition to enhancing their chemotactic and chemokinetic activity [12]. This evidence concerns the gene TNF and non-small cell lung carcinoma.