Furthermore, the integration of genome-wide association studies (GWAS) with quantitative trait analyses (eQTLs) have identified that the expression of an endolysosome-residing enzyme, that is the beta-mannosidase (MANBA), is lower in the kidneys of subjects with chronic kidney disease (CKD), and that the MANBA risk allele shows evidence of structural and functional defects in endolysosome and autophagy pathways in kidney tubule cells [8]. This evidence concerns the gene MANBA and chronic kidney disease.