SQSTM1 and cystinosis: Regardless of the mechanisms involved, the concept that defects in endolysosomes and autophagy pathways might contribute to cystinosis pathogenesis is in line with recent studies that indicate an accumulation of autophagosomes engulfing damaged and/or dysfunction mitochondria, and increased formation of aggregate-prone SQSTM1/p62 inclusions in both kidney biopsies [98,99] and patient cells [100].