CD274 and non-small cell lung carcinoma: Although the JAVELIN Lung 200 primary analysis revealed that avelumab did not significantly prolong OS versus docetaxel in patients with platinum-treated PD-L1 positive NSCLC, post-hoc analyses after two years of follow-up revealed that the two-year OS rates were doubled with avelumab in subgroups with higher PD-L1 expression.