Given the large and growing number of reports implicating overexpression of flotillins in the poor survival prognosis and high metastatic progression in a wide range of cancers [37,38], as well as data revealing the MPP1-related mechanism of drug resistance in leukemia [39], elucidation of the interplay between MPP1-flotillin and raft nanodomain organization might be helpful as a further potential therapeutic target. This evidence concerns the gene MPP1 and leukemia.