To that the detected ctDNA signals in the plasma of CRC patients are non-tumor-specific and actually a result of clonal hematopoiesis [32], BRAF p.V600E and KRAS p.G12/p.G13 analyses were performed on lymphocyte gDNA of all CRC patients with ctDNA-positive plasma samples (Figure 2, black line). Here, BRAF is linked to colorectal carcinoma.