In this regard, it is noteworthy that CXCR4 GOF heterozygous dominant mutations are responsible for the rare human immunodeficiency WHIM syndrome (for Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) featured by a panleukopenia and selective susceptibility to HPV-induced pathogenicity [119]. Here, CXCR4 is linked to WHIM syndrome.