As such, the downregulation of CXCL14 and CCL20 by HPV was respectively shown to jeopardize CD8+ T cell antitumor responses in HPV-tumors injected in mice [114] and associated with a reduced number of Langerhans cells in the HPV lesions of patients with the epidermodysplasia verruciformis (EV) skin disease [115]. The gene discussed is CCL20; the disease is epidermodysplasia verruciformis.