Some of the notable NK cell receptors that are associated with tumor surveillance and could provide therapeutic targets for leukemia treatment are natural killer group 2D (NKG2D), DNAM-1, PD-1, 2B4 (CD244, SLAMF4), CS1(CD319, SLAMF7), LLT1 (CLEC2D, OCIL), aKIRs and iKIRs, and natural cytotoxicity receptors (NCRs) such as NKp44, NKp30, and NKp46 (Figure 1). This evidence concerns the gene KLRD1 and leukemia.