TP53 and ovarian serous carcinoma: Recently, by culturing FTE and OSE cells as organoids and by introducing the same sets of mutations (i.e., p53 mutation, either alone or in combination with other oncogenic events), it was found that both cell types could serve as the cells-of-origin of high-grade serous ovarian carcinomas (HGSOCs); however, mutated FTE cells exhibited a shorter latency and higher penetrance of developing HGSOCs than similarly mutated OSE cells [41,42].