Integrated genomic studies of uterine cancer revealed that uterine serous tumors and high-grade endometrioid tumors have extensive copy number alterations and frequent TP53 mutations, whereas most endometrioid tumors have frequent mutations in the PTEN/PI3K, WNT, RAS, and SWI/SNF pathways [6]. The gene discussed is PTEN; the disease is endometrioid tumor.