For instance, the loss of both p53 and BRCA1 can lead to DNA damage and replication stress [43,44]; Müllerian-derived epithelial cells may be more sensitive to these challenges than mesothelial cells and, as a result, they are more likely to be transformed and become tumor-initiating cells in response to p53/BRCA1-loss. Here, BRCA1 is linked to neoplasm.