BRCA1 and ovary leiomyosarcoma: Lastly, the Ad-CMV-Cre-mediated inactivation of both Brca1 and p53 only led to the development of ovarian leiomyosarcomas [28,31]; however, when the Ad-CMV-Cre-mediated inactivation of p53 and Brca1 was combined with the inactivation of Rb1 and p107/p130 pocket proteins, the animals developed advanced serous ovarian cancers [29].