In both the Pten/Kras and Pten/Apc models, most malignancies were observed in their ovaries, including endometrioid hyperplasia, adenoma, and adenocarcinoma (negative for PAX8 staining), as well as poorly differentiated adenocarcinoma (Figure 5A–C: Pten/Kras; Figure 5D–F, Pten/Apc). This evidence concerns the gene KRAS and adenoma.