The loss of p53 in K8+ endometrial cells leads to the development of various endometrial malignancies, possibly including poorly differentiated adenocarcinoma and sarcoma, whereas the loss of p53 in K8+ FTE cells may lead to the development of serous adenocarcinoma and endometrioid adenocarcinoma in the ovary. The gene discussed is KRT8; the disease is endometrioid adenocarcinoma.