Using CD115 and Ly6G expression to distinguish monocytes (CD115high) from neutrophils (Ly6G+), we found that both monocytes and neutrophils increased in numbers even in control mice with age, but this effect was greater in late cancers and accounted for most if not all of the expansion of CD11b+ cells (Figure 1D,E). The gene discussed is ITGAM; the disease is cancer.