To further investigate the role of a special mitochondrial kinase on regulating p-Drp1Ser616, we focused on mitochondrial localization of PINK1 to elucidate the mechanism implicating mitochondrial protein machinery including mito-COX-2 and p-Drp1Ser616 in the mitochondrial dynamics of HCC cells. Here, PTGS2 is linked to hepatocellular carcinoma.