IF assay showed that SIRT3 was induced, and a reduction of COX-2 and SIRT3/COX-2 co-localization was suppressed in xenograft tumors from the RSV administration, suggesting SIRT3 was involved in the regulation of COX-2 deacetylation in cDDP-treated HCC xenograft tumors (Figure S8J). The gene discussed is SIRT3; the disease is hepatocellular carcinoma.