Taken together, these results indicated that targeting the intervention to Drp1 would be involved in suppressing the mito-COX-2/p-Drp1Ser616 interaction and its driven mitochondrial fission, which potentiates the pro-apoptotic effect and anti-tumor sensitivity in HCC cells treated with platinum drugs (Figure S7D). Here, DNM1L is linked to hepatocellular carcinoma.