In contrast, HCC xenografts with COX-2-knockdown exhibited a significantly lower percentage of COX-2- and p-Drp1Ser616-positive cells and reduced co-localization of COX-2 and p-Drp1Ser616 than those made of HepG2-Cas9-NC cells (Figure 5D). The gene discussed is PTGS2; the disease is hepatocellular carcinoma.