Tang et al. [49] found that COX-2 contributed to the upregulation of mitochondrial transcription factor A (TFAM), mediated by p38-MAPK activation, and the subsequent enhancement of Drp1-dependent mitochondrial fission in human osteosarcoma U-2 OS and cervical cancer HeLa cells. The gene discussed is PTGS2; the disease is cervical carcinoma.