Furthermore, in constructed SIRT3-overexpressing HCC cells, the cDDP-induced levels of pro-apoptotic proteins Bax and cleaved Caspase-3 were significantly increased and the reduction of anti-apoptotic protein Bcl-2 was decreased compared to control cells and cells treated with cDDP alone (Figure S8F). This evidence concerns the gene SIRT3 and hepatocellular carcinoma.