PTGS2 and neoplasm: Western blot analysis also confirmed the upregulation of COX-2 and Drp1 relative expression in HCC tumor tissues, while the quantitation and trend relationship analyses indicated that the levels of COX-2 and Drp1 were upregulated in tumor tissues compared to peritumor tissues, and there was a positive correlation between the levels of COX-2 and Drp1 expression in HCC sample tissues (r = 0.7558, p < 0.0001) (Figure 1D,E).