In an in silico study, Böttcher et al. [107] showed that the percentage of genome alterations in PCas from men included in The Cancer Genome Atlas Project (TCGA) and in the Canadian Prostate Cancer Genome Network (CPC-GENE) was three-fold higher in men with IDC-P/CC, and included deletions and amplifications in regions previously associated with aggressive PCa, such as 8p deletions (NKX3.1), 10q23 deletions (PTEN) and 8q amplifications (MYC). Here, PTEN is linked to posterior cortical atrophy.