Beyond ERG rearrangements, Bettendorf et al. [73] showed in 2008 that IDC-P was a distinct histopathological lesion from HGPIN, as comparative genomic hybridisation (CGH) revealed chromosomal imbalances in 8/11 IDC-P cases and in 0/10 HGPIN cases, with deletions at 8p, 10q and 13q; however, invasive carcinoma was not studied. This evidence concerns the gene ERG and invasive carcinoma.