TIMP1 and colorectal carcinoma: Chen and collaborators demonstrated that Mammalian STE20-like protein kinase 1/Serine threonine kinase 4 (MST1/STK4), S100 calcium-binding protein A9 (S100A9) and tissue inhibitor of metalloproteinases 1 (TIMP1) can be used as CRC biomarkers [83].