In this study, high expression of GPR64 was observed in Ewing sarcoma (90.9% [11/11]), chordoma (80.0% [12/15]), osteosarcoma (30.7% [4/13]), chondrosarcoma (36.3% [4/11]), fibrosarcoma (50% [2/4]), myxofibrosarcoma (16.6% [2/12]), dedifferentiated liposarcoma (15.4% [2/13]), and leiomyosarcoma (11.1% [1/9]) (Table 2). The gene discussed is ADGRG2; the disease is osteosarcoma.