In fact, although the data that PDK1 expression was moderate to strong in BC specimens (213/241, 88%) coincided with the findings in BC cells [35,37], PDK1 overexpression was not correlated with the mutation status of PIK3 CA in BC specimens, suggesting that PDK1 could be independently activated in BC and not just as a part of the PIK3 CA signaling pathway [37]. The gene discussed is PDK1; the disease is breast cancer.