AKT1 and breast cancer: As discussed earlier, PDK1 depletion in BC cells inhibited metastasis by reducing EGF-mediated chemotaxis and adhesion of tumor cells and aggregation of actin via the dampening of phosphorylation and translocation of AKT and PKCζ in a kinase-dependent manner, as well as suppressed tumorigenesis and lung colonization in SCID mice [32].