Similarly, the activated PDK1 displayed an especially important role either in carcinogenesis of MCF10 A cells induced by the concurrent mutations in both KRAS and PIK3 CA [39], or for the process of HRG/ERBB2-induced and enhanced transformation of BC cells (SKBR3, MCF7, and ZR-75–1 cells) via AKT/TSC2/mTOR [40]. Here, TSC2 is linked to breast cancer.