The result was that morphological changes including distorted multiacinar structures and cell foci coupled by interconnecting branching tracts, were shown in +PDK1 +NeuT MCF10 A cells, which shortly led to large muscle-invasive tumors in all SCID mice, indicating that PDK1 overexpression impelled ERBB2-induced transformation and tumor growth [38]. This evidence concerns the gene PDK1 and neoplasm.