Taken together with the study by our group on nonmetastatic CRC and the meta-analysis published by Yin et al. on unresectable metastatic CRC, these findings suggest that the interactions between KRAS and PTL exist across multiple stages of disease, ranging from nonmetastatic CRC to resectable and unresectable metastatic disease [25]. This evidence concerns the gene PNLIP and metastatic neoplasm.