IL6 and neoplasm: Third, sleep disturbance and long sleep duration are associated with increased systemic biomarkers of inflammation, such as C-reactive protein (CRP), interleukin 6 (IL-6), and fibrinogen [42,43]; systemic inflammation is a vital contributor to tumorigenesis, and medication that regulates inflammation, such as statins, may suppress tumor growth and increase the chance of survival [44,45].