As in lung squamous cell carcinoma, expression of genes critical to ribosome biogenesis strongly correlate with both PRKCI and ECT2 mRNA expression in the PDAC dataset (100/286 ribosome biogenesis genes p < 0.01 for both PRKCI and ECT2; see Table S2), suggesting PKCι-ECT2-signaling drives ribosome biogenesis in PDAC. This evidence concerns the gene ECT2 and squamous cell lung carcinoma.