Prkci∆panc mice were partially, but significantly, protected from an acute pancreatitis-induced increase in serum amylase (Figure 3B), and this treatment did not induce an increase in pancreas/body weight ratio in Prkci∆panc mice (Figure 3C), suggesting that loss of pancreatic PKCι expression reduced susceptibility to caerulein-induced acinar cell damage. This evidence concerns the gene PRKCI and acute pancreatitis.