We report that ablation of PKCι expression in the mouse pancreas altered the pancreatic immune cell population, reduced the severity of caerulein-induced pancreatitis, and blocked KrasG12D-driven progression of PanINs to pancreatic cancer, revealing for the first time a role for PKCι in the promotion of PDAC in mice. This evidence concerns the gene PRKCI and familial pancreatic carcinoma.