To address this question, we generated mice with KrasG12D-driven pancreatic cancer (KC GEMM) [8,27] and knockout of pancreatic Prkci by crossing Prkcif/f mice with KC mice to generate LSL-KrasG12D; Ptf1aCre/+; Prkcif/f (KCI) mice. This evidence concerns the gene PRKCI and familial pancreatic carcinoma.