miR-21 expression was significantly upregulated in ccRCC tissues compared to the normal renal tissues (14.48 ± 2.6 vs. 0.97 ± 0.1, respectively; p < 0.001; Figure 1A), whereas PPAR-α expression was significantly decreased (0.16 ± 0.03 vs. 1.03 ± 0.12, respectively; p < 0.001; Figure 1B). The gene discussed is PPARA; the disease is nonpapillary renal cell carcinoma.