The significantly higher pooled ORR in PD NENs than WD NENs, one of our main results, shares the same context with prior studies, which showed higher expression of PD-L1 and TMB in higher-grade NENs than in lower-grade NENs [53,54], which may explain the higher response rate in PD groups compared to WD groups. The gene discussed is CD274; the disease is Wilson disease.