Given the importance of EML4 in microtubule stability and the observation that EML4-ALK V3 fusion protein binds to microtubules [9,15], we hypothesised that a microtubule poison such as vincristine will be beneficial for sensitizing those NSCLC cells harbouring EML4-ALK V3 mutation. This evidence concerns the gene EML4 and non-small cell lung carcinoma.