In particular, when we considered the individual genes, ER chaperone BiP (HSPA5/BIP), eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3/PERK), and DNA damage-inducible transcript 3 (DDIT3/CHOP) were the most upregulated genes observed in CRC-SC#1, with a Log2FC of 3.46, 3.11, and 3.07, respectively. The gene discussed is EIF2AK3; the disease is colorectal carcinoma.