Notably, among the significantly downregulated genes in both HCT116 and CRC-SC#1 cells, we can mention the apoptosis inhibitor PIF1 5′-To-3′ DNA helicase (PIF1) [60] and the oncoprotein regulated by p53, PSRC1 (proline- and serine-rich coiled-coil 1/DDA3), required for normal progression through mitosis [61]. The gene discussed is TP53; the disease is colorectal carcinoma.