PIF1 downregulation is usually associated with decreased survival in neoplastic cells, but not in nonmalignant cells [60], whereas PSRC1 has been confirmed to be involved in microsatellite instability (MSI)—a genetic condition resulting from incompetent DNA mismatch repair, and frequently associated with CRC incidence and progression [166]. The gene discussed is PSRC1; the disease is colorectal carcinoma.